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Compound Detail

CHEMBL307721

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C=CCN1CC[C@@]2(C)c3cc(OC(=O)NC)ccc3N(C)[C@@H]12

Basic Information

ChEMBL ID CHEMBL307721
Phase Preclinical
Structure Type MOL
InChI Key AKAKQLGKPNQEPO-RDJZCZTQSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

301.4
MW (Da)
2.33
ALogP
4
HBA
1
HBD
44.8
PSA (Ų)
0.87
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H23N3O2
MW 301.39
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness 0.72

Activity Summary

IC50 5 meas. best 8.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cholinesterase
CHEMBL1914
IC50 8.52 8.16 3.0 2
Acetylcholinesterase
CHEMBL220
IC50 7.5 7.425 32.0 2
Acetylcholinesterase
CHEMBL4078
IC50 7.16 7.16 69.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2202827 10.1021/jm00171a001 Acetylcholinesterase 3
2202827 10.1021/jm00171a001 Cholinesterase 2

Data from ChEMBL 36 via Core Engine