Assay Detail
Binding
CHEMBL644788
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Inhibitory activity against Acetylcholinesterase in cortex
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Cortex |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.71 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74107 | — | — | 1 | 7.82 |
| CHEMBL305670 | — | — | 1 | 7.64 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 2 | 7.51 |
| CHEMBL307721 | — | — | 1 | 7.50 |
| CHEMBL74926 | PHENSERINE | — | 1 | 7.44 |
| CHEMBL75729 | — | — | 1 | 6.82 |
| CHEMBL74257 | — | — | 1 | 6.72 |
| CHEMBL74950 | — | — | 1 | 6.64 |
| CHEMBL308043 | — | — | 1 | 6.51 |
| CHEMBL308503 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74107 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL305670 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL307721 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL75729 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL74257 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL74950 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL308043 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL308503 | — | IC50 | = | 32000.0 | nM | 4.50 |