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Compound Detail

CHEMBL74107

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CCCCCCCCNC(=O)Oc1ccc2c(c1)[C@]1(C)CCN(C)[C@@H]1N2C

Basic Information

ChEMBL ID CHEMBL74107
Phase Preclinical
Structure Type MOL
InChI Key VSPVCSDDENDBFH-IRLDBZIGSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

373.5
MW (Da)
4.50
ALogP
4
HBA
1
HBD
44.8
PSA (Ų)
0.68
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H35N3O2
MW 373.54
Aromatic Rings 1
Heavy Atoms 27
NP-Likeness 0.69

Activity Summary

IC50 5 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cholinesterase
CHEMBL1914
IC50 8.4 8.225 4.0 2
Acetylcholinesterase
CHEMBL220
IC50 7.82 7.81 15.0 2
Acetylcholinesterase
CHEMBL4078
IC50 6.96 6.96 110.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2202827 10.1021/jm00171a001 Acetylcholinesterase 3
2202827 10.1021/jm00171a001 Cholinesterase 2

Data from ChEMBL 36 via Core Engine