Assay Detail
Binding
CHEMBL644789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Acetylcholinesterase in erythrocyte
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.68 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74107 | — | — | 1 | 7.80 |
| CHEMBL305670 | — | — | 1 | 7.68 |
| CHEMBL74926 | PHENSERINE | — | 1 | 7.68 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 2 | 7.46 |
| CHEMBL307721 | — | — | 1 | 7.35 |
| CHEMBL308043 | — | — | 1 | 6.68 |
| CHEMBL75729 | — | — | 1 | 6.66 |
| CHEMBL74257 | — | — | 1 | 6.48 |
| CHEMBL74950 | — | — | 1 | 6.46 |
| CHEMBL308503 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74107 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL305670 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL307721 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL308043 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL75729 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL74257 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL74950 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL308503 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 25000.0 | nM | 4.60 |