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Compound Detail

CHEMBL305670

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CNC(=O)Oc1ccc2c(c1)[C@]1(C)CCN[C@@H]1N2C

Basic Information

ChEMBL ID CHEMBL305670
Phase Preclinical
Structure Type MOL
InChI Key DWMBEPKCENULIA-OCCSQVGLSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

261.3
MW (Da)
1.43
ALogP
4
HBA
2
HBD
53.6
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H19N3O2
MW 261.32
Aromatic Rings 1
Heavy Atoms 19
NP-Likeness 0.88

Activity Summary

IC50 5 meas. best 8.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cholinesterase
CHEMBL1914
IC50 8.52 7.99 3.0 2
Acetylcholinesterase
CHEMBL220
IC50 7.68 7.66 21.0 2
Acetylcholinesterase
CHEMBL4078
IC50 7.24 7.24 57.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2202827 10.1021/jm00171a001 Acetylcholinesterase 3
2202827 10.1021/jm00171a001 Cholinesterase 2

Data from ChEMBL 36 via Core Engine