Assay Detail
Binding
CHEMBL884137
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Inhibitory activity against Butyrylcholinesterase in plasma
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Alfred Burger award address. Bioactive alkaloids. 4. Results of recent investigations with colchicine and physostigmine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.32 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75729 | — | — | 1 | 8.70 |
| CHEMBL305670 | — | — | 1 | 8.52 |
| CHEMBL307721 | — | — | 1 | 8.52 |
| CHEMBL74107 | — | — | 1 | 8.40 |
| CHEMBL74257 | — | — | 1 | 8.00 |
| CHEMBL94 | PHYSOSTIGMINE | 3.0 | 2 | 7.82 |
| CHEMBL74950 | — | — | 1 | 7.15 |
| CHEMBL308043 | — | — | 1 | 6.38 |
| CHEMBL74926 | PHENSERINE | — | 1 | 5.89 |
| CHEMBL308503 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75729 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL305670 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL307721 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL74107 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL74257 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL74950 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL308043 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL74926 | PHENSERINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL308503 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL94 | PHYSOSTIGMINE | IC50 | = | 4000.0 | nM | 5.40 |