Assay Detail
Functional
CHEMBL646236
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In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 5.93 | 6.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336161 | — | — | 1 | 6.73 |
| CHEMBL109783 | — | — | 1 | 6.50 |
| CHEMBL762 | OXYMETAZOLINE | 4.0 | 1 | 6.47 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 4.99 |
| CHEMBL1215 | PHENYLEPHRINE | 4.0 | 1 | 4.96 |
| CHEMBL133451 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336161 | — | EC50 | = | 186.21 | nM | 6.73 |
| CHEMBL109783 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL762 | OXYMETAZOLINE | EC50 | = | 338.84 | nM | 6.47 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL1215 | PHENYLEPHRINE | EC50 | = | 10964.78 | nM | 4.96 |
| CHEMBL133451 | — | EC50 | < | 100000.0 | nM | - |