Assay Detail
Binding
CHEMBL647245
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity for Adenosine A2A receptor from rat striatal membranes using [3H]-CGH 21680
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Derivatives of the triazoloquinazoline adenosine antagonist (CGS15943) are selective for the human A3 receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.69 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | — | 1 | 8.48 |
| CHEMBL340868 | — | — | 1 | 8.32 |
| CHEMBL7266 | — | — | 1 | 6.28 |
| CHEMBL89093 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16687 | CGS-15943 | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL340868 | — | IC50 | = | 4.77 | nM | 8.32 |
| CHEMBL7266 | — | IC50 | = | 531.0 | nM | 6.28 |
| CHEMBL89093 | — | IC50 | > | 100.0 | nM | - |