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Assay Detail

CHEMBL647934

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Binding
Inhibitory activity against aminopeptidase B
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Aminopeptidase B (CHEMBL2452)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.
Ocain TD, Rich DH.
J Med Chem (1988) 31 : 2193 -2199
PubMed 3184126 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 6.25 9.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL68509 1 9.04
CHEMBL305198 1 8.34
CHEMBL1204264 1 8.19
CHEMBL29292 UBENIMEX 2.0 1 7.22
CHEMBL69349 1 6.89
CHEMBL68979 1 5.62
CHEMBL69239 1 5.40
CHEMBL69814 1 5.16
CHEMBL69238 1 4.45
CHEMBL309130 1 4.41
CHEMBL69146 1 4.00
CHEMBL68686 1 -
CHEMBL68092 1 -
CHEMBL68511 1 -
CHEMBL71171 1 -
CHEMBL67868 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL68509 Ki = 0.91 nM 9.04
CHEMBL305198 Ki = 4.6 nM 8.34
CHEMBL1204264 Ki = 6.4 nM 8.19
CHEMBL29292 UBENIMEX Ki = 60.0 nM 7.22
CHEMBL69349 Ki = 130.0 nM 6.89
CHEMBL68979 Ki = 2400.0 nM 5.62
CHEMBL69239 Ki = 4000.0 nM 5.40
CHEMBL69814 Ki = 7000.0 nM 5.16
CHEMBL69238 Ki = 35700.0 nM 4.45
CHEMBL309130 Ki = 39000.0 nM 4.41
CHEMBL69146 Ki = 100000.0 nM 4.00
CHEMBL68686 Ki > 1000000.0 nM -
CHEMBL68092 Ki = 159000.0 nM -
CHEMBL68511 Ki > 200000.0 nM -
CHEMBL71171 Ki > 1000000.0 nM -
CHEMBL67868 Ki > 1000000.0 nM -