Compound Detail
CHEMBL1204264
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1204264 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QLHQXZPNNOOIED-UDYGKFQRSA-N |
| Parent Compound | CHEMBL305198 |
| Active Moiety | CHEMBL305198 |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
324.4
MW (Da)
1.47
ALogP
4
HBA
4
HBD
92.4
PSA (Ų)
0.54
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.19
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aminopeptidase B CHEMBL2452 | Ki | 8.19 | 8.19 | 6.4 | 1 |
| Cytosol aminopeptidase CHEMBL3965 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Aminopeptidase N CHEMBL2590 | Ki | 5.04 | 5.04 | 9100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aminopeptidase B | Ki | = | 6.4 | nM | 8.19 | Inhibitory activity against aminopeptidase B | 3184126 |
| Cytosol aminopeptidase | Ki | = | 1000.0 | nM | 6.0 | Inhibitory activity against Leucine aminopeptidase | 3184126 |
| Aminopeptidase N | Ki | = | 9100.0 | nM | 5.04 | Inhibitory activity against Aminopeptidase M | 3184126 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3184126 | 10.1021/jm00119a022 | Aminopeptidase N | 1 |
| 3184126 | 10.1021/jm00119a022 | Cytosol aminopeptidase | 1 |
| 3184126 | 10.1021/jm00119a022 | Aminopeptidase B | 1 |
Data from ChEMBL 36 via Core Engine