Assay Detail
Binding
CHEMBL706596
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Inhibitory activity against Leucine aminopeptidase
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Streptomyces olivoreticuli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 5.89 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29292 | UBENIMEX | 2.0 | 1 | 7.70 |
| CHEMBL68979 | — | — | 1 | 6.48 |
| CHEMBL309130 | — | — | 1 | 6.29 |
| CHEMBL305198 | — | — | 1 | 6.26 |
| CHEMBL1204264 | — | — | 1 | 6.00 |
| CHEMBL67868 | — | — | 1 | 5.36 |
| CHEMBL69238 | — | — | 1 | 4.58 |
| CHEMBL68686 | — | — | 1 | 4.48 |
| CHEMBL69239 | — | — | 1 | - |
| CHEMBL69814 | — | — | 1 | - |
| CHEMBL68092 | — | — | 1 | - |
| CHEMBL68511 | — | — | 1 | - |
| CHEMBL71171 | — | — | 1 | - |
| CHEMBL68509 | — | — | 1 | - |
| CHEMBL69349 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29292 | UBENIMEX | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL68979 | — | Ki | = | 330.0 | nM | 6.48 |
| CHEMBL309130 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL305198 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL1204264 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL67868 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL69238 | — | Ki | = | 26000.0 | nM | 4.58 |
| CHEMBL68686 | — | Ki | = | 33000.0 | nM | 4.48 |
| CHEMBL69239 | — | Ki | = | 167000.0 | nM | - |
| CHEMBL69814 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL68092 | — | Ki | = | 300000.0 | nM | - |
| CHEMBL68511 | — | Ki | = | 507000.0 | nM | - |
| CHEMBL71171 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL68509 | — | Ki | > | 1000000.0 | nM | - |
| CHEMBL69349 | — | Ki | = | 450000.0 | nM | - |