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Assay Detail

CHEMBL647938

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Binding
Inhibitory activity against Aminopeptidase M
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Aminopeptidase N (CHEMBL2590)
Type SINGLE PROTEIN
Organism Sus scrofa

Publication

Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.
Ocain TD, Rich DH.
J Med Chem (1988) 31 : 2193 -2199
PubMed 3184126 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 15 5.43 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL69349 1 7.70
CHEMBL68509 1 6.96
CHEMBL305198 1 5.36
CHEMBL69239 1 5.31
CHEMBL69814 1 5.22
CHEMBL29292 UBENIMEX 2.0 1 5.11
CHEMBL1204264 1 5.04
CHEMBL309130 1 4.70
CHEMBL69238 1 4.50
CHEMBL68979 1 4.39
CHEMBL68686 1 -
CHEMBL68092 1 -
CHEMBL68511 1 -
CHEMBL71171 1 -
CHEMBL67868 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL69349 Ki = 20.0 nM 7.70
CHEMBL68509 Ki = 110.0 nM 6.96
CHEMBL305198 Ki = 4400.0 nM 5.36
CHEMBL69239 Ki = 4900.0 nM 5.31
CHEMBL69814 Ki = 6000.0 nM 5.22
CHEMBL29292 UBENIMEX Ki = 7800.0 nM 5.11
CHEMBL1204264 Ki = 9100.0 nM 5.04
CHEMBL309130 Ki = 20000.0 nM 4.70
CHEMBL69238 Ki = 32000.0 nM 4.50
CHEMBL68979 Ki = 40300.0 nM 4.39
CHEMBL68686 Ki = 1000000.0 nM -
CHEMBL68092 Ki = 307000.0 nM -
CHEMBL68511 Ki = 355000.0 nM -
CHEMBL71171 Ki > 1000000.0 nM -
CHEMBL67868 Ki = 703000.0 nM -