Assay Detail
Binding
CHEMBL649839
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Prostate gland |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 8.99 | 9.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | 2.0 | 1 | 9.16 |
| CHEMBL419767 | — | — | 1 | 9.15 |
| CHEMBL425863 | MIBOLERONE | 2.0 | 1 | 9.12 |
| CHEMBL386630 | TESTOSTERONE | 4.0 | 1 | 8.85 |
| CHEMBL331820 | — | — | 1 | 8.65 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27769 | STANOLONE | Ki | = | 0.69 | nM | 9.16 |
| CHEMBL419767 | — | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL425863 | MIBOLERONE | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL386630 | TESTOSTERONE | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL331820 | — | Ki | = | 2.23 | nM | 8.65 |