Assay Detail
Functional
CHEMBL654478
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonistic potency at beta-1 adrenergic receptor for the percent maximal increase in contraction rate of isolated guinea pig atria
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Syntheses and adrenergic activities of ring-fluorinated epinephrines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.81 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43711 | — | — | 1 | 7.40 |
| CHEMBL679 | EPINEPHRINE | 4.0 | 1 | 6.58 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.46 |
| CHEMBL42359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43711 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL679 | EPINEPHRINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL1437 | NOREPINEPHRINE | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL42359 | — | EC50 | > | 1500.0 | nM | - |