Assay Detail
Binding
CHEMBL655219
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Ability to block Beta-2 adrenergic receptor in guinea pig trachea preparation
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Trachea |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 6.51 | 8.90 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281967 | — | — | 1 | 8.90 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 8.90 |
| CHEMBL13365 | — | — | 1 | 8.90 |
| CHEMBL281294 | — | — | 1 | 8.80 |
| CHEMBL284909 | — | — | 1 | 7.90 |
| CHEMBL13284 | — | — | 1 | 7.90 |
| CHEMBL31335 | — | — | 1 | 7.80 |
| CHEMBL281298 | — | — | 1 | 7.40 |
| CHEMBL31450 | — | — | 1 | 7.20 |
| CHEMBL13358 | — | — | 1 | 7.10 |
| CHEMBL30622 | — | — | 1 | 6.60 |
| CHEMBL31608 | — | — | 1 | 6.10 |
| CHEMBL30289 | — | — | 1 | 6.10 |
| CHEMBL31025 | — | — | 1 | 5.90 |
| CHEMBL6995 | PRACTOLOL | 4.0 | 1 | 5.80 |
| CHEMBL31036 | — | — | 1 | 5.70 |
| CHEMBL286894 | — | — | 1 | 5.50 |
| CHEMBL13504 | — | — | 1 | 5.50 |
| CHEMBL30899 | — | — | 1 | 5.40 |
| CHEMBL30292 | — | — | 1 | 5.40 |
| CHEMBL279777 | — | — | 1 | 5.20 |
| CHEMBL768 | ESMOLOL | 4.0 | 1 | 5.20 |
| CHEMBL31638 | — | — | 1 | 5.20 |
| CHEMBL31117 | — | — | 1 | 5.20 |
| CHEMBL31416 | — | — | 1 | 4.90 |
| CHEMBL31583 | — | — | 1 | 4.80 |
| CHEMBL31677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281967 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL27 | PROPRANOLOL | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL13365 | — | Kd | = | 1.259 | nM | 8.90 |
| CHEMBL281294 | — | Kd | = | 1.585 | nM | 8.80 |
| CHEMBL284909 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL13284 | — | Kd | = | 12.59 | nM | 7.90 |
| CHEMBL31335 | — | Kd | = | 15.85 | nM | 7.80 |
| CHEMBL281298 | — | Kd | = | 39.81 | nM | 7.40 |
| CHEMBL31450 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL13358 | — | Kd | = | 79.43 | nM | 7.10 |
| CHEMBL30622 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL31608 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL30289 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL31025 | — | Kd | = | 1258.93 | nM | 5.90 |
| CHEMBL6995 | PRACTOLOL | Kd | = | 1584.89 | nM | 5.80 |
| CHEMBL31036 | — | Kd | = | 1995.26 | nM | 5.70 |
| CHEMBL286894 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL13504 | — | Kd | = | 3162.28 | nM | 5.50 |
| CHEMBL30899 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL30292 | — | Kd | = | 3981.07 | nM | 5.40 |
| CHEMBL279777 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL768 | ESMOLOL | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL31638 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL31117 | — | Kd | = | 6309.57 | nM | 5.20 |
| CHEMBL31416 | — | Kd | = | 12589.25 | nM | 4.90 |
| CHEMBL31583 | — | Kd | = | 15848.93 | nM | 4.80 |
| CHEMBL31677 | — | Kd | > | 10000.0 | nM | - |