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Compound Detail

CHEMBL31335

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CCOC(=O)C(C)(C)NCC(O)COc1ccccc1C(=O)OC

Basic Information

ChEMBL ID CHEMBL31335
Phase Preclinical
Structure Type MOL
InChI Key RIUWFNRBLOATHM-UHFFFAOYSA-N
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

339.4
MW (Da)
1.14
ALogP
7
HBA
2
HBD
94.1
PSA (Ų)
0.65
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H25NO6
MW 339.39
Aromatic Rings 1
Heavy Atoms 24
NP-Likeness -0.72

Activity Summary

Kd 3 meas. best 8.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 8.0 6.5 10.0 2
Beta-2 adrenergic receptor
CHEMBL5414
Kd 7.8 7.8 15.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6130154 10.1021/jm00354a003 Beta-1 adrenergic receptor 2
6130154 10.1021/jm00354a003 Beta-2 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine