Assay Detail
Functional
CHEMBL690655
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h
16
Total Activities
16
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Ultra-short-acting beta-adrenergic receptor blocking agents. 2. (Aryloxy)propanolamines containing esters on the aryl function.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| In vivo duration | 14 | - | - |
| Kd | 2 | 7.50 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30622 | — | — | 1 | 10.00 |
| CHEMBL31335 | — | — | 1 | 5.00 |
| CHEMBL281298 | — | — | 1 | - |
| CHEMBL30289 | — | — | 1 | - |
| CHEMBL13284 | — | — | 1 | - |
| CHEMBL768 | ESMOLOL | 4.0 | 1 | - |
| CHEMBL13358 | — | — | 1 | - |
| CHEMBL30292 | — | — | 1 | - |
| CHEMBL31025 | — | — | 1 | - |
| CHEMBL286894 | — | — | 1 | - |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
| CHEMBL281967 | — | — | 1 | - |
| CHEMBL279777 | — | — | 1 | - |
| CHEMBL13365 | — | — | 1 | - |
| CHEMBL31638 | — | — | 1 | - |
| CHEMBL281294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30622 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL31335 | — | Kd | = | 10000.0 | nM | 5.00 |
| CHEMBL281298 | — | In vivo duration | = | 55.0 | Minutes | - |
| CHEMBL30289 | — | In vivo duration | > | 60.0 | Minutes | - |
| CHEMBL13284 | — | In vivo duration | = | 15.0 | Minutes | - |
| CHEMBL768 | ESMOLOL | In vivo duration | = | 12.0 | Minutes | - |
| CHEMBL13358 | — | In vivo duration | = | 30.0 | Minutes | - |
| CHEMBL30292 | — | In vivo duration | > | 60.0 | Minutes | - |
| CHEMBL31025 | — | In vivo duration | = | 15.0 | Minutes | - |
| CHEMBL286894 | — | In vivo duration | > | 60.0 | Minutes | - |
| CHEMBL27 | PROPRANOLOL | In vivo duration | > | 60.0 | Minutes | - |
| CHEMBL281967 | — | In vivo duration | = | 29.0 | Minutes | - |
| CHEMBL279777 | — | In vivo duration | = | 43.0 | Minutes | - |
| CHEMBL13365 | — | In vivo duration | = | 22.0 | Minutes | - |
| CHEMBL31638 | — | In vivo duration | = | 14.0 | Minutes | - |
| CHEMBL281294 | — | In vivo duration | = | 38.0 | Minutes | - |