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Compound Detail

CHEMBL30899

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COC(=O)c1ccc(OCC(O)CNC(C)(C)C)cc1

Basic Information

ChEMBL ID CHEMBL30899
Phase Preclinical
Structure Type MOL
InChI Key SZAYMQLNVXIKNC-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

281.4
MW (Da)
1.60
ALogP
5
HBA
2
HBD
67.8
PSA (Ų)
0.78
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H23NO4
MW 281.35
Aromatic Rings 1
Heavy Atoms 20
NP-Likeness -0.52

Activity Summary

Kd 2 meas. best 6.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL5471
Kd 6.5 6.5 316.2 1
Beta-2 adrenergic receptor
CHEMBL5414
Kd 5.4 5.4 3981.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6130154 10.1021/jm00354a003 Beta-1 adrenergic receptor 3
- 10.6019/CHEMBL3988442 Unchecked 3
- 10.6019/CHEMBL4513160 Pseudomonas aeruginosa 2
6130154 10.1021/jm00354a003 Beta-2 adrenergic receptor 1
- 10.6019/CHEMBL4513160 Acinetobacter baumannii 1

Data from ChEMBL 36 via Core Engine