Assay Detail
Binding
CHEMBL666232
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouse
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Dihydroorotate dehydrogenase (quinone), mitochondrial (CHEMBL2991) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis, structure-activity relationships, and pharmacokinetic properties of dihydroorotate dehydrogenase inhibitors: 2-cyano-3-cyclopropyl-3-hydroxy-N-[3'-methyl-4'-(trifluoromethyl)phenyl ] propenamide and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 6.12 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2111978 | — | — | 1 | 7.66 |
| CHEMBL960 | LEFLUNOMIDE | 4.0 | 1 | 7.52 |
| CHEMBL142214 | — | — | 1 | 7.44 |
| CHEMBL358411 | — | — | 1 | 7.44 |
| CHEMBL143518 | — | — | 1 | 7.44 |
| CHEMBL143116 | — | — | 1 | 7.40 |
| CHEMBL141195 | — | — | 1 | 7.38 |
| CHEMBL141732 | — | — | 1 | 7.33 |
| CHEMBL344556 | — | — | 1 | 7.30 |
| CHEMBL142218 | LAFLUNIMUS | 2.0 | 1 | 7.26 |
| CHEMBL344613 | — | — | 1 | 7.20 |
| CHEMBL142074 | — | — | 1 | 7.20 |
| CHEMBL973 | TERIFLUNOMIDE | 4.0 | 1 | 7.16 |
| CHEMBL357459 | — | — | 1 | 7.15 |
| CHEMBL356115 | — | — | 1 | 7.05 |
| CHEMBL141248 | — | — | 1 | 7.00 |
| CHEMBL143237 | — | — | 1 | 6.80 |
| CHEMBL140558 | — | — | 1 | 6.80 |
| CHEMBL344913 | — | — | 1 | 6.76 |
| CHEMBL141774 | — | — | 1 | 6.75 |
| CHEMBL141047 | — | — | 1 | 6.75 |
| CHEMBL343081 | — | — | 1 | 6.75 |
| CHEMBL141086 | — | — | 1 | 6.71 |
| CHEMBL143052 | — | — | 1 | 6.70 |
| CHEMBL337130 | — | — | 1 | 6.68 |
| CHEMBL141104 | — | — | 1 | 6.55 |
| CHEMBL139937 | — | — | 1 | 6.55 |
| CHEMBL141040 | — | — | 1 | 6.54 |
| CHEMBL358621 | — | — | 1 | 6.38 |
| CHEMBL143816 | — | — | 1 | 6.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2111978 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL960 | LEFLUNOMIDE | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL358411 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL143518 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL142214 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL143116 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL141195 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL141732 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL344556 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL142218 | LAFLUNIMUS | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL344613 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL142074 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL973 | TERIFLUNOMIDE | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL357459 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL356115 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL141248 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL143237 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL140558 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL344913 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL141774 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL141047 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL343081 | — | IC50 | = | 178.0 | nM | 6.75 |
| CHEMBL141086 | — | IC50 | = | 195.0 | nM | 6.71 |
| CHEMBL143052 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL337130 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL141104 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL139937 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL141040 | — | IC50 | = | 288.0 | nM | 6.54 |
| CHEMBL358621 | — | IC50 | = | 417.0 | nM | 6.38 |
| CHEMBL143816 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL140115 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL143196 | — | IC50 | = | 562.0 | nM | 6.25 |
| CHEMBL141126 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL139647 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL141237 | — | IC50 | = | 832.0 | nM | 6.08 |
| CHEMBL139954 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL341877 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL142996 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL141041 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL142705 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL344996 | — | IC50 | = | 2090.0 | nM | 5.68 |
| CHEMBL341721 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL141074 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL141015 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL334922 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL139818 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL344405 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL143319 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL141472 | — | IC50 | = | 4270.0 | nM | 5.37 |
| CHEMBL139699 | — | IC50 | = | 5000.0 | nM | 5.30 |