Assay Detail
Binding
CHEMBL666702
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Inhibitory activity against dihydrofolate reductase DHFR in rat liver
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.60 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.52 |
| CHEMBL313553 | — | — | 1 | 6.55 |
| CHEMBL313034 | — | — | 1 | 6.41 |
| CHEMBL87383 | — | — | 1 | 6.35 |
| CHEMBL313680 | — | — | 1 | 6.21 |
| CHEMBL87013 | — | — | 1 | 6.16 |
| CHEMBL314001 | — | — | 1 | 6.07 |
| CHEMBL85573 | — | — | 1 | 5.89 |
| CHEMBL88004 | — | — | 1 | 5.79 |
| CHEMBL444587 | — | — | 1 | 5.75 |
| CHEMBL313440 | — | — | 1 | 5.68 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 5.64 |
| CHEMBL85958 | — | — | 1 | 5.48 |
| CHEMBL314387 | — | — | 1 | 5.48 |
| CHEMBL85576 | — | — | 1 | 5.43 |
| CHEMBL87549 | — | — | 1 | 5.42 |
| CHEMBL85188 | — | — | 1 | 5.42 |
| CHEMBL85875 | — | — | 1 | 5.41 |
| CHEMBL82853 | — | — | 1 | 5.33 |
| CHEMBL315297 | — | — | 1 | 5.24 |
| CHEMBL87730 | — | — | 1 | 5.21 |
| CHEMBL2114205 | — | — | 1 | 5.19 |
| CHEMBL2115210 | — | — | 1 | 5.19 |
| CHEMBL87423 | — | — | 1 | 5.18 |
| CHEMBL298538 | — | — | 1 | 5.16 |
| CHEMBL86085 | — | — | 1 | 5.13 |
| CHEMBL85919 | — | — | 1 | 5.08 |
| CHEMBL313131 | — | — | 1 | 4.95 |
| CHEMBL441062 | — | — | 1 | 4.83 |
| CHEMBL49246 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119 | TRIMETREXATE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL313553 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL313034 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL87383 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL313680 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL87013 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL314001 | — | IC50 | = | 845.0 | nM | 6.07 |
| CHEMBL85573 | — | IC50 | = | 1290.0 | nM | 5.89 |
| CHEMBL88004 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL444587 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL313440 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL85958 | — | IC50 | = | 3330.0 | nM | 5.48 |
| CHEMBL314387 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL85576 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL87549 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL85188 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL85875 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL82853 | — | IC50 | = | 4670.0 | nM | 5.33 |
| CHEMBL315297 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL87730 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL2114205 | — | IC50 | = | 6510.0 | nM | 5.19 |
| CHEMBL2115210 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL87423 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL298538 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL86085 | — | IC50 | = | 7350.0 | nM | 5.13 |
| CHEMBL85919 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL313131 | — | IC50 | = | 11230.0 | nM | 4.95 |
| CHEMBL441062 | — | IC50 | = | 14900.0 | nM | 4.83 |
| CHEMBL49246 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL55764 | — | IC50 | = | 19400.0 | nM | 4.71 |