Assay Detail
Functional
CHEMBL669550
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for agonistic activity on rat dorsal root ganglion neurons (thought to express GluR5 receptors)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Dorsal root ganglion |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutamate receptor ionotropic, kainate 1 (CHEMBL2919) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.36 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301536 | — | — | 1 | 6.10 |
| CHEMBL51660 | — | — | 1 | 5.98 |
| CHEMBL275040 | KAINIC ACID | 2.0 | 1 | 4.92 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 4.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301536 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL51660 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL275040 | KAINIC ACID | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 35200.0 | nM | 4.45 |