Assay Detail
Binding
CHEMBL669679
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Binding activity against Dopamine receptor D1 in rat brain, using [3H]SCH-23390 as the radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.86 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72162 | — | — | 1 | 7.68 |
| CHEMBL72220 | — | — | 1 | 7.13 |
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 6.72 |
| CHEMBL308843 | — | — | 1 | 6.52 |
| CHEMBL73082 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72162 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL72220 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL42 | CLOZAPINE | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL308843 | — | IC50 | = | 305.0 | nM | 6.52 |
| CHEMBL73082 | — | IC50 | = | 540.0 | nM | 6.27 |