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Compound Detail

CHEMBL73082

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CC(C)=C1c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21

Basic Information

ChEMBL ID CHEMBL73082
Phase Preclinical
Structure Type MOL
InChI Key HYAGQWNRZOZWBC-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

364.9
MW (Da)
5.24
ALogP
2
HBA
0
HBD
6.5
PSA (Ų)
0.68
QED
1
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H25ClN2
MW 364.92
Aromatic Rings 2
Heavy Atoms 26
NP-Likeness -0.16

Activity Summary

IC50 5 meas. best 6.88

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(1A) dopamine receptor
CHEMBL265
IC50 6.88 6.575 133.0 2
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 6.53 6.455 297.0 2
D(2) dopamine receptor
CHEMBL339
IC50 5.32 5.32 4750.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2571728 10.1021/jm00130a006 Muscarinic acetylcholine receptor 1
2571728 10.1021/jm00130a006 D(1A) dopamine receptor 1
2571728 10.1021/jm00130a006 D(2) dopamine receptor 1
1967652 10.1021/jm00164a053 Muscarinic acetylcholine receptor 1
1967652 10.1021/jm00164a053 D(1A) dopamine receptor 1
1967652 10.1021/jm00164a053 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine