Assay Detail
Binding
CHEMBL748801
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Binding activity against muscarinic acetylcholine receptor in rat brain using [3H]QNB as the radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Sterically hindered 5,11-dicarbo analogues of clozapine as potential chiral antipsychotic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.19 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL72162 | — | — | 1 | 6.82 |
| CHEMBL73082 | — | — | 1 | 6.38 |
| CHEMBL72220 | — | — | 1 | 5.99 |
| CHEMBL308843 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL72162 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL73082 | — | IC50 | = | 415.0 | nM | 6.38 |
| CHEMBL72220 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL308843 | — | IC50 | = | 2600.0 | nM | 5.58 |