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Compound Detail

CHEMBL308843

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C/C=C1/c2ccccc2C=C(N2CCN(C)CC2)c2cc(Cl)ccc21

Basic Information

ChEMBL ID CHEMBL308843
Phase Preclinical
Structure Type MOL
InChI Key GPGQEGGSDSKZFR-ZUWFHJRGSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

350.9
MW (Da)
4.85
ALogP
2
HBA
0
HBD
6.5
PSA (Ų)
0.72
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H23ClN2
MW 350.89
Aromatic Rings 2
Heavy Atoms 25
NP-Likeness -0.18

Activity Summary

IC50 3 meas. best 6.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(1A) dopamine receptor
CHEMBL265
IC50 6.52 6.52 305.0 1
Muscarinic acetylcholine receptor
CHEMBL1907609
IC50 5.58 5.58 2600.0 1
D(2) dopamine receptor
CHEMBL339
IC50 5.16 5.16 6970.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2571728 10.1021/jm00130a006 Muscarinic acetylcholine receptor 1
2571728 10.1021/jm00130a006 D(1A) dopamine receptor 1
2571728 10.1021/jm00130a006 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine