Assay Detail
Binding
CHEMBL670519
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The affinity for the Dopamine receptor D2 was assessed by the inhibition of [3H]-spiperone binding in rat striatal membranes in vitro.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potential antipsychotic agents. 7. Synthesis and antidopaminergic properties of the atypical highly potent (S)-5-bromo-2,3-dimethoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide and related compounds. A comparative study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.78 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289330 | — | — | 1 | 8.92 |
| CHEMBL76402 | — | — | 1 | 8.85 |
| CHEMBL75876 | — | — | 1 | 8.77 |
| CHEMBL77492 | — | — | 1 | 8.72 |
| CHEMBL75842 | — | — | 1 | 8.30 |
| CHEMBL301532 | — | — | 1 | 8.14 |
| CHEMBL305916 | — | — | 1 | 8.06 |
| CHEMBL76266 | — | — | 1 | 8.00 |
| CHEMBL283099 | — | — | 1 | 7.92 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.50 |
| CHEMBL74970 | — | — | 1 | 7.36 |
| CHEMBL75447 | — | — | 1 | 7.34 |
| CHEMBL419832 | — | — | 1 | 7.34 |
| CHEMBL75887 | — | — | 1 | 7.28 |
| CHEMBL2114141 | — | — | 1 | 6.84 |
| CHEMBL307491 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289330 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL76402 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL75876 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL77492 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL75842 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL301532 | — | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL305916 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL76266 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL283099 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL74970 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL75447 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL419832 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL75887 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL2114141 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL307491 | — | IC50 | = | 8210.0 | nM | 5.09 |