Assay Detail
Binding
CHEMBL670968
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for its affinity (pKi) to inhibit [3H]spiperone binding to the dopamine receptor D2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and antidopaminergic activity of some 3-(aminomethyl)tetralones as analogues of butyrophenone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.54 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL310153 | — | — | 1 | 8.19 |
| CHEMBL308480 | — | — | 1 | 7.68 |
| CHEMBL310734 | — | — | 1 | 7.60 |
| CHEMBL73675 | — | — | 1 | 7.13 |
| CHEMBL72649 | — | — | 1 | 7.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL310153 | — | Ki | = | 6.457 | nM | 8.19 |
| CHEMBL308480 | — | Ki | = | 20.89 | nM | 7.68 |
| CHEMBL310734 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL73675 | — | Ki | = | 74.13 | nM | 7.13 |
| CHEMBL72649 | — | Ki | = | 77.62 | nM | 7.11 |