Assay Detail
Binding
CHEMBL671406
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2 in rat striatal membranes.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.48 | 9.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907702 | — | — | 1 | 9.11 |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.04 |
| CHEMBL76402 | — | — | 1 | 8.85 |
| CHEMBL1907692 | — | — | 1 | 8.77 |
| CHEMBL3085403 | — | — | 1 | 8.72 |
| CHEMBL1907700 | — | — | 1 | 8.64 |
| CHEMBL1907695 | — | — | 1 | 8.62 |
| CHEMBL305916 | — | — | 1 | 8.06 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.92 |
| CHEMBL283099 | — | — | 1 | 7.92 |
| CHEMBL1907697 | — | — | 1 | 7.72 |
| CHEMBL1907693 | — | — | 1 | 7.68 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 7.50 |
| CHEMBL3085402 | — | — | 1 | 7.48 |
| CHEMBL1907694 | — | — | 1 | 7.36 |
| CHEMBL1907691 | — | — | 1 | 7.25 |
| CHEMBL1907690 | — | — | 1 | 7.17 |
| CHEMBL1907698 | — | — | 1 | 7.15 |
| CHEMBL1907915 | — | — | 1 | 7.10 |
| CHEMBL1907696 | — | — | 1 | 6.69 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 6.68 |
| CHEMBL1907701 | — | — | 1 | 6.38 |
| CHEMBL16252 | — | — | 1 | 6.09 |
| CHEMBL1907699 | — | — | 1 | 5.76 |
| CHEMBL1907703 | — | — | 1 | 5.53 |
| CHEMBL1907914 | — | — | 1 | 5.21 |
| CHEMBL416352 | — | — | 1 | - |
| CHEMBL1907913 | — | — | 1 | - |
| CHEMBL16135 | — | — | 1 | - |
| CHEMBL1202419 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907702 | — | IC50 | = | 0.77 | nM | 9.11 |
| CHEMBL8946 | ETICLOPRIDE | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL76402 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL1907692 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL3085403 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL1907700 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL1907695 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL305916 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL54 | HALOPERIDOL | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL283099 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1907697 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1907693 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3085402 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL1907694 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL1907691 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL1907690 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL1907698 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL1907915 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL1907696 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL267044 | LEVOSULPIRIDE | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1907701 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL16252 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL1907699 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL1907703 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL1907914 | — | IC50 | = | 6170.0 | nM | 5.21 |
| CHEMBL416352 | — | IC50 | - | nM | - | |
| CHEMBL1907913 | — | IC50 | - | nM | - | |
| CHEMBL16135 | — | IC50 | - | nM | - | |
| CHEMBL1202419 | — | IC50 | - | nM | - | |
| CHEMBL16160 | — | IC50 | - | nM | - | |
| CHEMBL416355 | — | IC50 | - | nM | - |