Compound Detail
CHEMBL1907915
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Basic Information
| ChEMBL ID | CHEMBL1907915 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WGLPSCZHULDZSS-SNVBAGLBSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
387.3
MW (Da)
2.39
ALogP
5
HBA
2
HBD
71.0
PSA (Ų)
0.78
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.1
Ki 1 meas. best 8.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| D(2) dopamine receptor CHEMBL339 | Ki | 8.18 | 8.18 | 6.5 | 1 |
| D(2) dopamine receptor CHEMBL339 | IC50 | 7.1 | 7.1 | 79.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| D(2) dopamine receptor | Ki | = | 6.54 | nM | 8.18 | Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D... | 1969484 |
| D(2) dopamine receptor | IC50 | = | 79.0 | nM | 7.1 | In vitro ability to inhibit the binding of [3H]spiperone to dopamine receptor D2... | 1969484 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1969484 | 10.1021/jm00166a012 | D(2) dopamine receptor | 2 |
| 1969484 | 10.1021/jm00166a012 | Rattus norvegicus | 2 |
Data from ChEMBL 36 via Core Engine