Assay Detail
Binding
CHEMBL675802
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]spiperone binding to rat striatal membrane Dopamine receptor D2
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Potential antipsychotic agents 5. Synthesis and antidopaminergic properties of substituted 5,6-dimethoxysalicylamides and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 9.37 | 10.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907695 | — | — | 1 | 10.64 |
| CHEMBL1907702 | — | — | 1 | 10.48 |
| CHEMBL76402 | — | — | 1 | 10.19 |
| CHEMBL1907692 | — | — | 1 | 10.06 |
| CHEMBL8946 | ETICLOPRIDE | 2.0 | 1 | 9.92 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 9.48 |
| CHEMBL283099 | — | — | 1 | 9.26 |
| CHEMBL305916 | — | — | 1 | 9.12 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.89 |
| CHEMBL1907915 | — | — | 1 | 8.18 |
| CHEMBL267044 | LEVOSULPIRIDE | 2.0 | 1 | 8.16 |
| CHEMBL1907690 | — | — | 1 | 8.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907695 | — | Ki | = | 0.023 | nM | 10.64 |
| CHEMBL1907702 | — | Ki | = | 0.033 | nM | 10.48 |
| CHEMBL76402 | — | Ki | = | 0.064 | nM | 10.19 |
| CHEMBL1907692 | — | Ki | = | 0.087 | nM | 10.06 |
| CHEMBL8946 | ETICLOPRIDE | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 0.33 | nM | 9.48 |
| CHEMBL283099 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL305916 | — | Ki | = | 0.75 | nM | 9.12 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1907915 | — | Ki | = | 6.54 | nM | 8.18 |
| CHEMBL267044 | LEVOSULPIRIDE | Ki | = | 6.9 | nM | 8.16 |
| CHEMBL1907690 | — | Ki | = | 8.38 | nM | 8.08 |