Assay Detail
Binding
CHEMBL671490
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Binding affinity at Dopamine receptor D2 in rat striatal membrane by [3H]spiperone displacement.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Aryl 1-but-3-ynyl-4-phenyl-1,2,3,6-tetrahydropyridines as potential antipsychotic agents: synthesis and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.94 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | 2.0 | 1 | 8.04 |
| CHEMBL108790 | — | — | 1 | 7.52 |
| CHEMBL110489 | — | — | 1 | 7.50 |
| CHEMBL109063 | — | — | 1 | 7.48 |
| CHEMBL108463 | — | — | 1 | 7.43 |
| CHEMBL108186 | — | — | 1 | 7.40 |
| CHEMBL321828 | — | — | 1 | 7.25 |
| CHEMBL109101 | — | — | 1 | 7.20 |
| CHEMBL324445 | — | — | 1 | 7.14 |
| CHEMBL108375 | — | — | 1 | 6.90 |
| CHEMBL110488 | — | — | 1 | 6.87 |
| CHEMBL109199 | — | — | 1 | 6.71 |
| CHEMBL108462 | — | — | 1 | 6.59 |
| CHEMBL108530 | — | — | 1 | 6.49 |
| CHEMBL419021 | — | — | 1 | 6.36 |
| CHEMBL110843 | — | — | 1 | 5.78 |
| CHEMBL432972 | — | — | 1 | 5.27 |
| CHEMBL110136 | — | — | 1 | - |
| CHEMBL108386 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431367 | ROXINDOLE | Ki | = | 9.1 | nM | 8.04 |
| CHEMBL108790 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL110489 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL109063 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL108463 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL108186 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL321828 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL109101 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL324445 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL108375 | — | Ki | = | 127.0 | nM | 6.90 |
| CHEMBL110488 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL109199 | — | Ki | = | 193.0 | nM | 6.71 |
| CHEMBL108462 | — | Ki | = | 255.0 | nM | 6.59 |
| CHEMBL108530 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL419021 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL110843 | — | Ki | = | 1673.0 | nM | 5.78 |
| CHEMBL432972 | — | Ki | = | 5388.0 | nM | 5.27 |
| CHEMBL110136 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL108386 | — | Ki | > | 10000.0 | nM | - |