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Compound Detail

CHEMBL108530

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COc1ccc(C#CCCN2CC=C(c3ccccc3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL108530
Phase Preclinical
Structure Type MOL
InChI Key DRTKYNKXTWRNKR-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

317.4
MW (Da)
4.23
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.78
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H23NO
MW 317.43
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -0.51

Activity Summary

Ki 2 meas. best 6.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
Ki 6.49 6.49 323.6 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8759640 10.1021/jm950721m D(2) dopamine receptor 1
8759640 10.1021/jm950721m Mus musculus 1
8759640 10.1021/jm950721m Rattus norvegicus 1
15808487 10.1016/j.bmcl.2005.02.012 D(2) dopamine receptor 1

Data from ChEMBL 36 via Core Engine