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Assay Detail

CHEMBL835388

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Binding
Binding affinity towards dopamine receptor D2 of rat striatal membrane was determined
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL339)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

The role of QSAR in dopamine interactions.
Hansch C, Verma RP, Kurup A, Mekapati SB.
Bioorg Med Chem Lett (2005) 15 : 2149 -2157
PubMed 15808487 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 16 7.03 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL108790 1 7.52
CHEMBL110489 1 7.49
CHEMBL109063 1 7.48
CHEMBL108463 1 7.43
CHEMBL108531 1 7.32
CHEMBL109171 1 7.27
CHEMBL109101 1 7.20
CHEMBL324445 1 7.14
CHEMBL108532 1 7.06
CHEMBL108375 1 6.90
CHEMBL110488 1 6.87
CHEMBL321858 1 6.74
CHEMBL109199 1 6.71
CHEMBL110324 1 6.55
CHEMBL108530 1 6.49
CHEMBL419021 1 6.36

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL108790 Ki = 30.2 nM 7.52
CHEMBL110489 Ki = 32.36 nM 7.49
CHEMBL109063 Ki = 33.11 nM 7.48
CHEMBL108463 Ki = 37.15 nM 7.43
CHEMBL108531 Ki = 47.86 nM 7.32
CHEMBL109171 Ki = 53.7 nM 7.27
CHEMBL109101 Ki = 63.1 nM 7.20
CHEMBL324445 Ki = 72.44 nM 7.14
CHEMBL108532 Ki = 87.1 nM 7.06
CHEMBL108375 Ki = 125.89 nM 6.90
CHEMBL110488 Ki = 134.9 nM 6.87
CHEMBL321858 Ki = 181.97 nM 6.74
CHEMBL109199 Ki = 194.98 nM 6.71
CHEMBL110324 Ki = 281.84 nM 6.55
CHEMBL108530 Ki = 323.59 nM 6.49
CHEMBL419021 Ki = 436.52 nM 6.36