Assay Detail
Functional
CHEMBL671648
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Effective concentration required for agonistic activity against rat D2 long receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Fused azaindole derivatives: molecular design, synthesis and in vitro pharmacology leading to the preferential dopamine D3 receptor agonist FAUC 725.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.88 | 8.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | 4.0 | 1 | 8.04 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 7.72 |
| CHEMBL80845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL301265 | PRAMIPEXOLE | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL7549 | PRECLAMOL | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL80845 | — | EC50 | > | 1000.0 | nM | - |