Assay Detail
Binding
CHEMBL674068
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition constant against dopamine receptor D2 in rat
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Fluorinated and iodinated dopamine agents: D2 imaging agents for PET and SPECT.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 9.54 | 10.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308524 | IOXIPRIDE | — | 1 | 10.72 |
| CHEMBL42953 | — | — | 1 | 10.70 |
| CHEMBL44237 | EPIDEPRIDE | — | 1 | 10.60 |
| CHEMBL431384 | — | — | 1 | 9.97 |
| CHEMBL73683 | — | — | 1 | 9.83 |
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 9.37 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.96 |
| CHEMBL307023 | IODOSULPIRIDE | — | 1 | 8.82 |
| CHEMBL49897 | IODOPRIDE | — | 1 | 8.52 |
| CHEMBL305844 | — | — | 1 | 7.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308524 | IOXIPRIDE | Ki | = | 0.019 | nM | 10.72 |
| CHEMBL42953 | — | Ki | = | 0.02 | nM | 10.70 |
| CHEMBL44237 | EPIDEPRIDE | Ki | = | 0.025 | nM | 10.60 |
| CHEMBL431384 | — | Ki | = | 0.106 | nM | 9.97 |
| CHEMBL73683 | — | Ki | = | 0.147 | nM | 9.83 |
| CHEMBL267723 | IOLOPRIDE | Ki | = | 0.43 | nM | 9.37 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL307023 | IODOSULPIRIDE | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL49897 | IODOPRIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL305844 | — | Ki | = | 13.0 | nM | 7.89 |