Assay Detail
Binding
CHEMBL675089
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In vitro inhibition of [3H]N-0437 binding to Dopamine receptor D2 in rat striatal membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.95 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7806 | — | — | 1 | 9.21 |
| CHEMBL7850 | — | — | 1 | 7.35 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 7.26 |
| CHEMBL268240 | — | — | 1 | 7.12 |
| CHEMBL7393 | — | — | 1 | 7.01 |
| CHEMBL8074 | — | — | 1 | 6.77 |
| CHEMBL7449 | — | — | 1 | 6.50 |
| CHEMBL7381 | — | — | 1 | 6.24 |
| CHEMBL2051756 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7806 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL7850 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL7549 | PRECLAMOL | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL268240 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL7393 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL8074 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL7449 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL7381 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2051756 | — | IC50 | = | 7900.0 | nM | 5.10 |