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Compound Detail

CHEMBL7381

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Oc1cccc(C2CCCN3CCCCC23)c1

Basic Information

ChEMBL ID CHEMBL7381
Phase Preclinical
Structure Type MOL
InChI Key RUTLNJGVITWMQE-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

231.3
MW (Da)
3.12
ALogP
2
HBA
1
HBD
23.5
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C15H21NO
MW 231.34
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness 0.41

Activity Summary

IC50 2 meas. best 6.24

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
IC50 6.24 5.565 580.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3806591 10.1021/jm00384a024 Rattus norvegicus 8
1968512 10.1021/jm00165a020 Rattus norvegicus 8
1968512 10.1021/jm00165a020 D(2) dopamine receptor 2

Data from ChEMBL 36 via Core Engine