Assay Detail
Binding
CHEMBL675090
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In vitro inhibition of [3H]spiperone binding to Dopamine receptor D2 in rat striatal membranes
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Pre- and postsynaptic dopaminergic activities of indolizidine and quinolizidine derivatives of 3-(3-hydroxyphenyl)-N-(n-propyl)piperidine (3-PPP). Further developments of a dopamine receptor model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.41 | 8.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7806 | — | — | 1 | 8.06 |
| CHEMBL7549 | PRECLAMOL | 2.0 | 1 | 5.47 |
| CHEMBL268240 | — | — | 1 | 5.42 |
| CHEMBL7850 | — | — | 1 | 5.31 |
| CHEMBL7449 | — | — | 1 | 5.28 |
| CHEMBL8074 | — | — | 1 | 5.19 |
| CHEMBL7381 | — | — | 1 | 4.89 |
| CHEMBL7393 | — | — | 1 | 4.64 |
| CHEMBL2051756 | — | — | 1 | 4.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7806 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL7549 | PRECLAMOL | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL268240 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL7850 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL7449 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL8074 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL7381 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL7393 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL2051756 | — | IC50 | = | 40000.0 | nM | 4.40 |