Assay Detail
Binding
CHEMBL675746
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Binding affinity of [3H]U-86170 towards Dopamine receptor D2 in cloned mammalian receptor expressed in cultured cells or from rat whole brain
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
(S)-(-)-4-[4-[2-(isochroman-1-yl)ethyl]-piperazin-1-yl] benzenesulfonamide, a selective dopamine D4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.33 | 7.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | 4.0 | 1 | 7.26 |
| CHEMBL81330 | — | — | 1 | 6.80 |
| CHEMBL83915 | — | — | 1 | 6.40 |
| CHEMBL63329 | — | — | 1 | 6.28 |
| CHEMBL71724 | — | — | 1 | 5.96 |
| CHEMBL81649 | — | — | 1 | 5.25 |
| CHEMBL82591 | — | — | 1 | - |
| CHEMBL69759 | SONEPIPRAZOLE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42 | CLOZAPINE | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL81330 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL83915 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL63329 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL71724 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL81649 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL82591 | — | Ki | > | 1800.0 | nM | - |
| CHEMBL69759 | SONEPIPRAZOLE | Ki | > | 4300.0 | nM | - |