Assay Detail
Binding
CHEMBL675755
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In vivo inhibitory activity against dopamine (D2) receptor in rat caudate-putamen tissue
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and affinity of a possible byproduct of electrophilic radiolabeling of [123I]IBZM.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.71 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 8.77 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.14 |
| CHEMBL283099 | — | — | 1 | 7.68 |
| CHEMBL23519 | — | — | 1 | 7.25 |
| CHEMBL423331 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267723 | IOLOPRIDE | IC50 | = | 1.71 | nM | 8.77 |
| CHEMBL8809 | RACLOPRIDE | IC50 | = | 7.2 | nM | 8.14 |
| CHEMBL283099 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL23519 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL423331 | — | IC50 | = | 196.0 | nM | 6.71 |