Assay Detail
Binding
CHEMBL675767
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]-raclopride binding at Dopamine receptor D2 in rat brain membranes.
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.55 | 6.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1203894 | — | — | 1 | 6.39 |
| CHEMBL1202296 | — | — | 1 | 5.92 |
| CHEMBL177620 | — | — | 1 | 5.23 |
| CHEMBL174632 | — | — | 1 | 4.66 |
| CHEMBL177624 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1203894 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL1202296 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL177620 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL174632 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL177624 | — | IC50 | = | 105000.0 | nM | - |