Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL1203894

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
COc1ccc(C2CCN(CCCCc3ccccc3)CC2)cc1.Cl

Basic Information

ChEMBL ID CHEMBL1203894
Phase Preclinical
Structure Type MOL
InChI Key ZIVPPZVHTNOLCK-UHFFFAOYSA-N
Parent Compound CHEMBL175097
Active Moiety CHEMBL175097
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

323.5
MW (Da)
4.90
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.67
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H30ClNO
MW 359.94
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -0.63

Activity Summary

IC50 2 meas. best 6.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
IC50 6.39 6.39 410.0 1
Adrenergic receptor alpha-1
CHEMBL1907610
IC50 5.77 5.77 1700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
10715162 10.1021/jm990428c Glutamate NMDA receptor; Grin1/Grin2a 1
10715162 10.1021/jm990428c Glutamate NMDA receptor; Grin1/Grin2b 1
10715162 10.1021/jm990428c Glutamate NMDA receptor; Grin1/Grin2c 1
10715162 10.1021/jm990428c Adrenergic receptor alpha-1 1
10715162 10.1021/jm990428c D(2) dopamine receptor 1
10715162 10.1021/jm990428c Mus musculus 1

Data from ChEMBL 36 via Core Engine