Assay Detail
Binding
CHEMBL676137
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Competitive binding assay against Dopamine receptor D2 in rat striatal membranes and [125I]-IBF radioligand
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.48 | 10.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | 2.0 | 1 | 10.82 |
| CHEMBL48450 | — | — | 1 | 10.07 |
| CHEMBL267723 | IOLOPRIDE | 2.0 | 1 | 9.58 |
| CHEMBL8809 | RACLOPRIDE | 2.0 | 1 | 8.96 |
| CHEMBL1255588 | — | — | 1 | 8.92 |
| CHEMBL301532 | — | — | 1 | 8.41 |
| CHEMBL26736 | — | — | 1 | 7.18 |
| CHEMBL51 | KETANSERIN | 3.0 | 1 | 6.31 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 6.07 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267930 | SPIPERONE | Ki | = | 0.015 | nM | 10.82 |
| CHEMBL48450 | — | Ki | = | 0.085 | nM | 10.07 |
| CHEMBL267723 | IOLOPRIDE | Ki | = | 0.261 | nM | 9.58 |
| CHEMBL8809 | RACLOPRIDE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL1255588 | — | Ki | = | 1.19 | nM | 8.92 |
| CHEMBL301532 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL26736 | — | Ki | = | 65.7 | nM | 7.18 |
| CHEMBL51 | KETANSERIN | Ki | = | 491.0 | nM | 6.31 |
| CHEMBL59 | DOPAMINE | Ki | = | 843.0 | nM | 6.07 |
| CHEMBL27 | PROPRANOLOL | Ki | > | 10000.0 | nM | - |