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Compound Detail

CHEMBL48450

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CCN1CCC[C@H]1CNC(=O)c1cc(I)cc2c1OCC2

Basic Information

ChEMBL ID CHEMBL48450
Phase Preclinical
Structure Type MOL
InChI Key SXAMDWYVBFWJLU-ZDUSSCGKSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

400.3
MW (Da)
2.44
ALogP
3
HBA
1
HBD
41.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H21IN2O2
MW 400.26
Aromatic Rings 1
Heavy Atoms 21
NP-Likeness -1.06

Activity Summary

Ki 2 meas. best 10.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
D(2) dopamine receptor
CHEMBL339
Ki 10.07 9.855 0.1 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2136916 10.1021/jm00163a029 Rattus norvegicus 60
2136916 10.1021/jm00163a029 D(2) dopamine receptor 2

Data from ChEMBL 36 via Core Engine