Assay Detail
Binding
CHEMBL678176
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In vivo compound was evaluated for binding towards Dopamine receptor D2 in rat striatal membranes using competitive binding assay and [125I]IBZM radioligand
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and characterization of iodobenzamide analogues: potential D-2 dopamine receptor imaging agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.10 | 9.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48450 | — | — | 1 | 9.64 |
| CHEMBL50484 | — | — | 1 | 7.52 |
| CHEMBL49898 | — | — | 1 | 7.09 |
| CHEMBL301399 | — | — | 1 | 6.87 |
| CHEMBL301133 | — | — | 1 | 6.78 |
| CHEMBL48721 | — | — | 1 | 6.55 |
| CHEMBL296978 | — | — | 1 | 6.29 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48450 | — | Ki | = | 0.23 | nM | 9.64 |
| CHEMBL50484 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL49898 | — | Ki | = | 82.0 | nM | 7.09 |
| CHEMBL301399 | — | Ki | = | 135.0 | nM | 6.87 |
| CHEMBL301133 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL48721 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL296978 | — | Ki | = | 507.0 | nM | 6.29 |
| CHEMBL62 | SCH-23390 | Ki | = | 820.0 | nM | 6.09 |