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Assay Detail

CHEMBL676159

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Binding
Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).
ChEMBL ↗
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Epidermal growth factor receptor (CHEMBL203) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
Sun L, Tran N, Tang F, App H, Hirth P, McMahon G, Tang C.
J Med Chem (1998) 41 : 2588 -2603
PubMed 9651163 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 54 4.78 5.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL89505 — — 1 5.10
CHEMBL89723 — — 1 5.02
CHEMBL85021 — — 1 4.82
CHEMBL48760 — — 1 4.73
CHEMBL87746 — — 1 4.72
CHEMBL86326 — — 1 4.71
CHEMBL314146 — — 1 4.36
CHEMBL421548 — — 1 -
CHEMBL90277 — — 1 -
CHEMBL316020 — — 1 -
CHEMBL89483 — — 1 -
CHEMBL87325 — — 1 -
CHEMBL316009 — — 1 -
CHEMBL314021 — — 1 -
CHEMBL420411 — — 1 -
CHEMBL86631 — — 1 -
CHEMBL329367 — — 1 -
CHEMBL313259 — — 1 -
CHEMBL328710 — — 1 -
CHEMBL330321 — — 1 -
CHEMBL88405 — — 1 -
CHEMBL315546 — — 1 -
CHEMBL86921 — — 1 -
CHEMBL89721 — — 1 -
CHEMBL86944 — — 1 -
CHEMBL87324 — — 1 -
CHEMBL276711 SEMAXANIB 3.0 1 -
CHEMBL89697 — — 1 -
CHEMBL431025 — — 1 -
CHEMBL89809 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL89505 — IC50 = 7900.0 nM 5.10
CHEMBL89723 — IC50 = 9500.0 nM 5.02
CHEMBL85021 — IC50 = 15300.0 nM 4.82
CHEMBL48760 — IC50 = 18500.0 nM 4.73
CHEMBL87746 — IC50 = 19000.0 nM 4.72
CHEMBL86326 — IC50 = 19300.0 nM 4.71
CHEMBL314146 — IC50 = 44000.0 nM 4.36
CHEMBL86837 — IC50 > 100000.0 nM -
CHEMBL90277 — IC50 > 100000.0 nM -
CHEMBL87402 — IC50 > 100000.0 nM -
CHEMBL87208 — IC50 > 100000.0 nM -
CHEMBL89363 — IC50 > 100000.0 nM -
CHEMBL86945 — IC50 > 100000.0 nM -
CHEMBL87080 — IC50 > 10000.0 nM -
CHEMBL86943 — IC50 > 100000.0 nM -
CHEMBL86755 — IC50 > 100000.0 nM -
CHEMBL85403 — IC50 > 100000.0 nM -
CHEMBL316268 — IC50 > 100000.0 nM -
CHEMBL328452 — IC50 > 100000.0 nM -
CHEMBL89040 — IC50 > 100000.0 nM -
CHEMBL86432 — IC50 > 100000.0 nM -
CHEMBL89646 — IC50 > 100000.0 nM -
CHEMBL86480 — IC50 > 100000.0 nM -
CHEMBL314217 — IC50 > 100000.0 nM -
CHEMBL313578 — IC50 > 100000.0 nM -
CHEMBL314798 — IC50 > 100000.0 nM -
CHEMBL316008 — IC50 > 100000.0 nM -
CHEMBL87783 — IC50 > 100000.0 nM -
CHEMBL330321 — IC50 > 100000.0 nM -
CHEMBL89809 — IC50 > 100000.0 nM -
CHEMBL431025 — IC50 > 100000.0 nM -
CHEMBL89697 — IC50 > 100000.0 nM -
CHEMBL276711 SEMAXANIB IC50 > 100000.0 nM -
CHEMBL87324 — IC50 > 100000.0 nM -
CHEMBL86944 — IC50 > 100000.0 nM -
CHEMBL89721 — IC50 > 100000.0 nM -
CHEMBL86921 — IC50 > 100000.0 nM -
CHEMBL315546 — IC50 > 100000.0 nM -
CHEMBL88405 — IC50 > 50000.0 nM -
CHEMBL313259 — IC50 > 100000.0 nM -
CHEMBL328710 — IC50 > 100000.0 nM -
CHEMBL421548 — IC50 > 10000.0 nM -
CHEMBL316020 — IC50 > 100000.0 nM -
CHEMBL89483 — IC50 > 100000.0 nM -
CHEMBL87325 — IC50 > 100000.0 nM -
CHEMBL316009 — IC50 > 100000.0 nM -
CHEMBL314021 — IC50 > 100000.0 nM -
CHEMBL420411 — IC50 > 100000.0 nM -
CHEMBL86631 — IC50 > 100000.0 nM -
CHEMBL329367 — IC50 > 100000.0 nM -