Assay Detail
Binding
CHEMBL677401
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Effective concentration against Endothelin B receptor from rat cerebellum
30
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebellum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of C-terminal endothelin hexapeptide antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 6.13 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313984 | — | — | 2 | 7.70 |
| CHEMBL327350 | — | — | 1 | 7.44 |
| CHEMBL1788127 | — | — | 1 | 7.16 |
| CHEMBL313760 | — | — | 1 | 7.16 |
| CHEMBL89736 | — | — | 1 | 6.82 |
| CHEMBL85341 | — | — | 1 | 6.60 |
| CHEMBL406279 | — | — | 1 | 6.54 |
| CHEMBL313382 | — | — | 1 | 6.35 |
| CHEMBL87243 | — | — | 1 | 6.35 |
| CHEMBL313056 | — | — | 1 | 6.08 |
| CHEMBL315047 | — | — | 1 | 5.72 |
| CHEMBL86814 | — | — | 1 | 5.70 |
| CHEMBL2370070 | — | — | 1 | 5.61 |
| CHEMBL87252 | — | — | 1 | 5.58 |
| CHEMBL315328 | — | — | 1 | 5.58 |
| CHEMBL316092 | — | — | 1 | 5.34 |
| CHEMBL289687 | — | — | 1 | 5.04 |
| CHEMBL315658 | — | — | 1 | 5.03 |
| CHEMBL315780 | — | — | 1 | 5.01 |
| CHEMBL273391 | — | — | 1 | 4.73 |
| CHEMBL315384 | — | — | 1 | - |
| CHEMBL431218 | — | — | 1 | - |
| CHEMBL431874 | — | — | 1 | - |
| CHEMBL87724 | — | — | 1 | - |
| CHEMBL86737 | — | — | 1 | - |
| CHEMBL312916 | — | — | 1 | - |
| CHEMBL314239 | — | — | 1 | - |
| CHEMBL330489 | — | — | 1 | - |
| CHEMBL89416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313984 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL327350 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL313984 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL1788127 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL313760 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL89736 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL85341 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL406279 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL87243 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL313382 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL313056 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL315047 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL86814 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2370070 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL87252 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL315328 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL316092 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL289687 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL315658 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL315780 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL273391 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL312916 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL86737 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL431874 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL431218 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL315384 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL87724 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL314239 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL330489 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL89416 | — | IC50 | > | 10000.0 | nM | - |