Assay Detail
Binding
CHEMBL680019
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Inhibitory concentration was evaluated against epidermal growth factor receptor (EGFr) tyrosine kinase
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2-Substituted aminopyrido[2,3-d]pyrimidin-7(8H)-ones. structure-activity relationships against selected tyrosine kinases and in vitro and in vivo anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 6.26 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111197 | — | — | 1 | 7.52 |
| CHEMBL320705 | — | — | 1 | 7.18 |
| CHEMBL113070 | — | — | 1 | 7.10 |
| CHEMBL327127 | — | — | 1 | 7.05 |
| CHEMBL321193 | — | — | 1 | 6.82 |
| CHEMBL109631 | — | — | 1 | 6.72 |
| CHEMBL322298 | — | — | 1 | 6.70 |
| CHEMBL104244 | — | — | 1 | 6.68 |
| CHEMBL50647 | — | — | 1 | 6.66 |
| CHEMBL104153 | — | — | 1 | 6.66 |
| CHEMBL113023 | — | — | 1 | 6.60 |
| CHEMBL301612 | — | — | 1 | 6.58 |
| CHEMBL324926 | — | — | 1 | 6.48 |
| CHEMBL111339 | — | — | 1 | 6.32 |
| CHEMBL448154 | — | — | 1 | 6.31 |
| CHEMBL325589 | — | — | 1 | 6.29 |
| CHEMBL111434 | — | — | 1 | 6.17 |
| CHEMBL419022 | — | — | 1 | 6.16 |
| CHEMBL104779 | — | — | 1 | 6.04 |
| CHEMBL113863 | — | — | 1 | 6.00 |
| CHEMBL111365 | — | — | 1 | 5.89 |
| CHEMBL50470 | — | — | 1 | 5.85 |
| CHEMBL332269 | — | — | 1 | 5.36 |
| CHEMBL109296 | — | — | 1 | 5.35 |
| CHEMBL106232 | — | — | 1 | 5.35 |
| CHEMBL49596 | — | — | 1 | 5.25 |
| CHEMBL107472 | — | — | 1 | 5.12 |
| CHEMBL299194 | — | — | 1 | 5.06 |
| CHEMBL111247 | — | — | 1 | - |
| CHEMBL109525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111197 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL320705 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL113070 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL327127 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL321193 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL109631 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL322298 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL104244 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL50647 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL104153 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL113023 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL301612 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL324926 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL111339 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL448154 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL325589 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL111434 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL419022 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL104779 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL113863 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL111365 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL50470 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL332269 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL109296 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL106232 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL49596 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL107472 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL299194 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL111618 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL109759 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL299347 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL113356 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL326041 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL48172 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL110034 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL323699 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL113128 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL109525 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL111247 | — | IC50 | > | 5000.0 | nM | - |