Compound Detail
CHEMBL111365
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL111365 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NBPINIBREWXSRV-UHFFFAOYSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
428.3
MW (Da)
4.45
ALogP
7
HBA
1
HBD
81.9
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL3655 | IC50 | 7.11 | 7.11 | 77.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 6.27 | 6.27 | 540.0 | 1 |
| Epidermal growth factor receptor CHEMBL203 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 77.0 | nM | 7.11 | Inhibition of avian c-Src tyrosine kinase | 9703473 |
| Platelet-derived growth factor receptor beta | IC50 | = | 400.0 | nM | 6.4 | Inhibitory concentration was evaluated against Platelet-derived growth factor re... | 9703473 |
| Fibroblast growth factor receptor 1 | IC50 | = | 540.0 | nM | 6.27 | Inhibitory concentration evaluated against fibroblast growth factor receptor 1. | 9703473 |
| Epidermal growth factor receptor | IC50 | = | 1300.0 | nM | 5.89 | Inhibitory concentration was evaluated against epidermal growth factor receptor ... | 9703473 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9703473 | 10.1021/jm9802259 | Platelet-derived growth factor receptor beta | 1 |
| 9703473 | 10.1021/jm9802259 | Fibroblast growth factor receptor 1 | 1 |
| 9703473 | 10.1021/jm9802259 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 9703473 | 10.1021/jm9802259 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine