Compound Detail
CHEMBL113356
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Basic Information
| ChEMBL ID | CHEMBL113356 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GCVONYYXPDJZOE-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
411.3
MW (Da)
4.91
ALogP
5
HBA
1
HBD
59.8
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.98
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src CHEMBL3655 | IC50 | 4.98 | 4.98 | 10400.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 4.62 | 4.62 | 23800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase Src | IC50 | = | 10400.0 | nM | 4.98 | Inhibition of avian c-Src tyrosine kinase | 9703473 |
| Fibroblast growth factor receptor 1 | IC50 | = | 14000.0 | nM | 4.85 | Inhibitory concentration evaluated against fibroblast growth factor receptor 1. | 9703473 |
| Platelet-derived growth factor receptor beta | IC50 | = | 23800.0 | nM | 4.62 | Inhibitory concentration was evaluated against Platelet-derived growth factor re... | 9703473 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27038496 | 10.1016/j.bmcl.2016.03.077 | Gamma-secretase | 2 |
| 9703473 | 10.1021/jm9802259 | Platelet-derived growth factor receptor beta | 1 |
| 9703473 | 10.1021/jm9802259 | Fibroblast growth factor receptor 1 | 1 |
| 9703473 | 10.1021/jm9802259 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 9703473 | 10.1021/jm9802259 | Epidermal growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine